Calexico is a city in Imperial County, California. The population was 38,572 at the 2010 census, up from 27,109 at the 2000 census. Calexico is about 122 miles east of San Diego and 62 miles west of Yuma, Arizona. The name of the city is a portmanteau of California and Mexico, which, like that of its adjacent sister city of Mexicali, emphasizes its identity as a border city.Major events every year are the Mariachi festival on March 25 followed by the SDSU "Perspective of the Latino Race" art exhibition on April 3.